Effects of Tartrazine on Different Contractile Stimuli in Guinea Pig Tracheal Muscle

Publisher Website
Google Scholar
Abstract
Tracheal smooth muscle obtained from ovalbumin-sensitized guinea pigs contracted with micromolar concentrations of tartrazine [a food and drug odor additive] and indomethacin. The contractions were slightly reduced by clemastine, but were completely blocked by the SRS-A [slow reacting substanace of anaphylaxis] antagonist FPL 55712 (7-[3-4-acetyl-3-hydroxy-2-propylphenoxy-2-hydroxy-propoxy]-4-oxo-3-propyl-4H-1-benzopyran-2-carboxylic acid monosodium salt). Arylsulfatase B, which is an enzyme that inactivates SRS-A, also abolished the contractions induced by tartrazine. Contractions induced by carbacholine histamine, egg albumin and arachidonic acid were slightly reduced by indomethacin and tartrazine. Tartrazine like indomethacin inhibited the generation of thromboxanes from human platelts. SRS-A apparently plays an important role in the immediate hypersensitivity reactions of tartrazine and indomethacin in guinea pig trachea.

This publication has 18 references indexed in Scilit: