EFFECTS OF CORTISONE ON EXPERIMENTAL MURINE TYPHUS III

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Abstract
Effects of cortisone on immunity and the immune response in the mouse, cotton rat, hamster, guinea pig, and rabbit were studied. Cortisone had no effect on the development of immunity or on the resistance to challenge with murine typhus in the mouse. Cortisone had no effects on the immunization of rabbits with sonic treated or whole rickettsial antigens. Cortisone caused a slower development of complement fixing antibodies in the rabbit, although, by the 21st day in most instances a higher level of complement fixing antibody was present in the cortisone treated animals. Data for the cotton rat and hamster were inadequate to draw any conclusions concerning the effects of immunity on the development of the complement fixing titers.