Studies on vasculitis

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Abstract
Summary: The sera of persons with cutaneous vasculitis following bacterial infection were examined for antibacterial anaphylactic antibodies that could have predisposed tissues to deposition of harmful antigen‐antibody complexes.Sera of persons with or without cutaneous vasculitis after bacterial infection had no reagins to streptococcal or staphylococcal cellular or extracellular antigens detectable by monkey passive cutaneous anaphylaxis or histamine release from monkey lung, and no IgE antibodies to the extracellular antigens were found by radio‐immunodiffusion precipitation gel tests. One person with, and one without, vasculitis after streptococcal tonsilitis had heat‐stable short‐term passive sensitizing antibodies mediating increased vascular permeability in monkey skin, and one person had reagins to Candida albicans cellular antigens.The sera of three persons sensitive to tetanus toxoid were used to control the reliability of the above tests. One serum mediated monkey PC A and histamine release from monkey lung, and all three were found to contain IgE anti‐tetanus toxoid antibodies.It is concluded that either small amounts of IgE reagin to lipopolysaccharides are not detected due to technical difficulties, or anaphylactic sensitivity to polysaccharides may sometimes be mediated by other classes of antibody.