Effect of elcatonin on experimental gastric and duodenal ulcers.

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Abstract
The antiulcer action of elcatonin, an analog of natural eel calcitonin, was compared with that of cimetidine, secretin and solcoseryl. Elcatonin (3-10 U/kg, s.c.) inhibited the development of gastric ulcers induced by pylorus ligation, water-immersion stress, aspirin and reserpine, and it inhibited duodenal ulcers induced by cysteamine in rats. Once daily injections of elcatonin (1-10 U/kg per day, s.c.) promoted the healing of acetic acid-induced chronic gastric ulcers not only in rats, but also in dogs. The healing effect persisted after the cessation of administrations. Cimetidine (30-100 mg/kg, per os) inhibited the development of gastric ulcers induced by water-immersion stress, aspirin and reserpine, and inhibited duodenal ulcers induced by cysteamine in rats. Once daily administrations of cimetidine (30-100 mg/kg per day, per os) did not show significant effect on acetic acid-induced chronic gastric ulcers in rats. Secretin (30-100 U/kg, s.c.) inhibited the development of gastric ulcers induced by pylorus ligation, water-immersion stress, aspirin and reserpine in rats, but was not effective on cysteamine-induced duodenal ulcers and acetic acid-induced chronic gastric ulcers in rats. Solcoseryl (2 ml/kg, s.c.) inhibited only the development of water-immersion stress-induced gastric ulcers in rats. Elcatonin is different from these reference drugs in its properties of action on experimental ulcers. Mechanisms of the antiulcer action of elcatonin, which has a superior effect on experimental ulcers, are discussed.