Effects of certain analeptic drugs on spontaneous running activity of the white rat.

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Abstract
Young 100 gm. [female] white rats served as their own controls in an expt. in which interest centered in the * effects of various drugs and dosages of drugs on running activity (measured by means of revolving cages). All injns. (subcut.) were made at 9:00 A.M. and running records kept for the next 7 hrs. One or more dosages of the following drugs were employed: benzedrine sulphate, Z-ephedrine hydrochloride, propadrine hydrochloride, epinephrine hydrochloride, neosynephrine, caffeine sodioben-zoate, cocaine hydrochloride, coramine, picrotoxin, metrazol. Cocaine was "the most effective stimulus for running." When drugs were administered orally with food over a period of 21 days, "the effects are much less intense and may be modified after a few days by the development of tolerance.".

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