17-ALPHA-HYDROXYPROGESTERONE AND THE VIRILISM OF THE ADRENOGENITAL SYNDROME ASSOCIATED WITH CONGENITAL ADRENOCORTICAL HYPERPLASIA — A REVIEW
- 1 September 1956
- journal article
- review article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 16 (9) , 1262-1275
- https://doi.org/10.1210/jcem-16-9-1262
Abstract
This discussion can be summarized by one question: is the virilism of the adrenogenital syndrome induced by an excess of 17-alpha-hydroxyprogesterone, as postulated by Jailer and associates or is it induced by an excess of unidentified androgenic adrenal steroids, as proposed by Bartter and associates? Dorf-man has suggested that the masculinization results from large amounts of C-19 androgens (such as [DELTA]4-androstene, 3,17-dione) which are synthesized by the adrenal glands from acetate or cholesterol but not by way of the C-21 precursors (such as 17-alpha-hydroxyprogesterone). One of the important steps in answering this question is to determine whether or not 17-alpha-hydroxy- progesterone is a biologically active androgen when given paren-terally in man.Keywords
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