Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
Open Access
- 19 August 1998
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 280 (7) , 614-618
- https://doi.org/10.1001/jama.280.7.614
Abstract
ALZHEIMER DISEASE (AD) is a neurodegenerative disorder that manifests clinically with pervasive and progressive deficits in cognition and memory that are accompanied by characteristic neuropathologic changes including extracellular amyloid plaque deposition, intraneuronal neurofibrillary tangles, and neuronal loss.1 Epidemiological and molecular genetic data suggest that although there are likely multiple etiologies for AD, genetic factors play a prominent role.This publication has 10 references indexed in Scilit:
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