Double‐blind study of oral γ‐vinyl GABA in the treatment of dystonia
- 1 January 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (1) , 98
- https://doi.org/10.1212/wnl.36.1.98
Abstract
Six patients with different forms of dystonia were treated with γ-vinyl GABA, a specific enzyme-activated inhibitor of GABA-trans-aminase, in a double-blind, placebo-controlled crossover study, γ-Vinyl GABA therapy, 2 g daily for 2 weeks, was compared with placebo by weekly assessments. There were no consistent changes in three evaluation scores. Agents that augment CNS GABA are unlikely to benefit patients with generalized dystonia.This publication has 13 references indexed in Scilit:
- High dosage anticholinergic therapy in dystoniaNeurology, 1983
- Gamma-vinyl-GABA: A single-blind trial in patients with epilepsyActa Neurologica Scandinavica, 1983
- Effect of gamma-vinyl GABA in tardive dyskinesiaPsychiatry Research, 1983
- Idiopathic dystonia: Neuropharmacological studyZeitschrift für Neurologie, 1982
- Dystonia Musculorum DeformansArchives of Neurology, 1982
- A double‐blind clinical trial of isoniazid in Huntington diseaseNeurology, 1982
- Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid)Life Sciences, 1981
- Treatment of Huntington disease with γ ‐acetylenic GABA, an irreversible inhibitor of GABA‐ transaminaseNeurology, 1981
- Effect of isoniazid on cerebrospinal fluid and plasma GABA levels in Huntington's diseaseLife Sciences, 1980
- γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE1Journal of Neurochemistry, 1977