The role of DNA breaks in genomic instability and tumorigenesis
- 7 July 2003
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 194 (1) , 77-95
- https://doi.org/10.1034/j.1600-065x.2003.00060.x
Abstract
Summary: DNA double‐strand breaks (DSBs) represent dangerous chromosomal lesions that can lead to mutation, neoplastic transformation, or cell death. DSBs can occur by extrinsic insult from environm...Keywords
This publication has 188 references indexed in Scilit:
- How DNA lesions are turned into mutations within cells?Oncogene, 2002
- Does Artemis End the Hunt for the Hairpin-Opening Activity in V(D)J Recombination?Cell, 2002
- Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: Identification of new amplification regions by fluorescence in situ hybridization and spectral karyotypingGenes, Chromosomes and Cancer, 2002
- Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome armsGenes, Chromosomes and Cancer, 2001
- Revising B Cell ReceptorsThe Journal of Experimental Medicine, 2000
- Cellular Origin of Human B-Cell LymphomasNew England Journal of Medicine, 1999
- Expression and Function of Recombination Activating Genes in Mature В CellsCritical Reviews in Immunology, 1998
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceNature, 1985
- Association of Multiple Copies of the N-mycOncogene with Rapid Progression of NeuroblastomasNew England Journal of Medicine, 1985
- Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomasCell, 1979