The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
- 1 December 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 318 (6046) , 533-538
- https://doi.org/10.1038/318533a0
Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.Keywords
This publication has 56 references indexed in Scilit:
- SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic miceNature, 1985
- Transgenic miceCell, 1985
- Activated Proto-onc Genes: Sufficient or Necessary for Cancer?Science, 1985
- Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse lineNature, 1985
- THE MOLECULAR GENETICS OF CELLULAR ONCOGENESAnnual Review of Genetics, 1984
- Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibodyCell, 1984
- High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytesNature, 1984
- Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumorsCell, 1984
- Expression of a microinjected immunoglobulin gene in the spleen of transgenic miceNature, 1983
- CELLULAR ONCOGENES AND RETROVIRUSESAnnual Review of Biochemistry, 1983