The Effect of Age, Gender, and Sexual Maturation on the Caffeine Breath Test

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Abstract
This study demonstrated the feasibility of utilizing the (3-13C-methyl) caffeine breath test (CBT) in children and adolescents, and examined the effect of gender, age, and puberty on the CBT. The CBT, expressed as the 2-hour accumulative exhalation of labeled CO(2) (2-hour CO(2)), was compared to the CBT results in the adult. The 2-hour CO(2) values were higher in the children than the adult, and the decrease in the CO(2) values occurred in males during late puberty and in females during early puberty.