Abstract
Intracerebroventricular injection of vasoactive intestinal polypeptide (VIP) into the rat caused a temporary elevation of body temperature followed by a decrease to below the control level. Hypothermia induced by cholecystokinin octapeptide was abolished by simultaneous administration of VIP. Hypothermia following pentobarbital administration was reduced by successive injections of VIP. Multiple interactions of neuropeptides may be involved in central thermoregulation.