Effects of Reserpine and Chlorpromazine on Nest Building and Thermal Preference in Rats

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Abstract
Effects of reserpine, chlorpromazine, and combined drugs on nest building and thermal preference of 24 rats were described. In the doses used, reserpine alone had a marked and persistent effect. It depressed nest building while reversing thermal preference from a cool to warm environment. This differential behavioral effect is thought to relate to the differences in persistence of activity required for the two tests and the ability of reserpine-treated animals to maintain alertness for brief periods after handling.

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