Lambda Chains in Cold Agglutinins

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Abstract
Type L light chains have been found in the cold agglutinins in the serums of three patients with chronic hemolytic anemia. Although two of these cold agglutinins are unusual in that they do not have specificity to I or i red-cell antigens (one of these has, in addition, cryoglobulin property), the third is a cold agglutinin of I specificity. Previously reported cold agglutinins from such patients have all been of type K; this is the first report of type L cold agglutinins associated with chronic hemolytic anemia.