Tetrahydrofuran Lignans from Nectandra megapotamica with Trypanocidal Activity
- 18 December 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 67 (1) , 42-45
- https://doi.org/10.1021/np0302697
Abstract
The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a−d, 2a−c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC50 value of 2.2 μM and lysis of 94% of the parasites at 32 μM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive.Keywords
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