Myeloperoxidase Activity of Polymorphonuclear Leukocytes in Iron Deficiency Anemia and Anemia of Chronic Disorders

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Abstract
Myeloperoxidase (MPO) activity was studied in adults with irons deficiency anemia (IDA) or anemia of chronic disorders (ACD). MPO activity (biochemical quantitation) was found to be decreased in IDA when compared to the control group (p < 0.05); ACD subjects also had lower values although the difference was not significant (p < 0.05). MPO scores (MPO staining) were significantly lower in IDA and ACD subjects than in the healthy control group (p < 0.05). A significant positive correlation was noted between ferritin (R = 0.40) and percent transferrin saturation (R = 0.37) and MPO activity (p < 0.001) in IDA and for the healthy controls.