Cyproheptadine Treatment in Neuroleptic-Induced Akathisia

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Abstract
Background Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia. Method In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D. Results All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued. Conclusions Cyproheptadine may be useful in neuroleptic-induced akathisia.

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