Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments
- 15 September 2004
- journal article
- Published by American Society of Hematology in Blood
- Vol. 104 (6) , 1656-1661
- https://doi.org/10.1182/blood-2004-01-0247
Abstract
The mutant tg/tg mice, which do not express mi transcription factor (MITF), lack mast cells in most tissues. Since MITF is expressed in both mast cells and tissues where mast cells develop, there is a possibility that the tg/tg mice may show abnormalities in both mast cell precursors and tissue environments. We examined this possibility by bone marrow and skin transplantation. When bone marrow cells of tg/tg mice were transplanted to W/Wv mice that possess normal tissue environment, mast cells did not develop in all tissues examined. The number of developing mast cells in the skin of W/Wv mice was much lower when grafted to tg/tg recipients than when grafted to normal (+/+) recipients. These results indicated that mast cell precursors of tg/tg mice were defective. When bone marrow cells of +/+ mice were transplanted, the number of developing mast cells was significantly lower in examined tissues of tg/tg recipients than in those of W/Wv recipients, suggesting that the tissue environment for mast cell development was defective in tg/tg mice. MITF appeared essential for the function of both mast cell precursors and tissue environments for their development. (Blood. 2004;104:1656-1661)Keywords
This publication has 29 references indexed in Scilit:
- Effect of Anatomical Distribution of Mast Cells on Their Defense Function against Bacterial InfectionsThe Journal of Experimental Medicine, 2003
- Additive effect of mouse genetic background and mutation ofMITF gene on decrease of skin mast cellsBlood, 2003
- Effect of a large deletion of the basic domain of mitranscription factor on differentiation of mast cellsBlood, 2001
- Importance of leucine zipper domain of mitranscription factor (MITF) for differentiation of mast cells demonstrated using mice/mice mutant mice of which MITF lacks the zipper domainBlood, 2001
- Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 geneBlood, 2001
- Heterogeneity of Mast Cells and Phenotypic Change Between SubpopulationsAnnual Review of Immunology, 1989
- Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.The Journal of Experimental Medicine, 1985
- Proliferation and differentiation in culture of mast cell progenitors derived from mast cell‐deficient mice of genotype W/WvJournal of Cellular Physiology, 1985
- Concentration of mast‐cell progenitors in bone marrow, spleen, and blood of mice determined by limiting dilution analysisJournal of Cellular Physiology, 1982
- Haematopoietic stem cell content of murine bone marrow, spleen, and blood. Limiting dilution analysis of diffusion chamber culturesJournal of Cellular Physiology, 1971