Control of Sindbis Virus Infection by Antibody in Interferon-Deficient Mice
Open Access
- 15 April 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (8) , 3905-3908
- https://doi.org/10.1128/jvi.74.8.3905-3908.2000
Abstract
Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.Keywords
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