Inhibition of Tumor cell Glycolysis by DPNH2, and Reversal of the Inhibition by DPN, Pyruvate or Methylene blue
Open Access
- 1 September 1963
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 18 (9) , 731-748
- https://doi.org/10.1515/znb-1963-0909
Abstract
The discovery of the active group of the hydrogen-transferring enzymes - nicotinamide -for which Otto Warburg was nominated by the Nobel Committee "for a prize for the second time in 1944, when he again was found to deserve the honor", has had a profound influence on all of biochemistry. The present paper describes a fundamental inhibition of intracellular tumor metabolism produced by reduced diphosphopyridine nucleotide (DPNH2) added extracellulary.Keywords
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