Molecular cloning of the cDNA encoding a receptor tyrosine kinase‐related molecule with a catalytic region homologous to c‐ met

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Abstract
Receptor tyrosine kinases mediate a range of growth and differentiation processes in multiple biological systems. In this work, we report the identification of a novel tyrosine kinase‐related molecule, nyk‐r, and the molecular cloning of its complete cDNA. Its extracellular domain bears no apparent homology with other receptor families, but its intracellular kinase‐related region has considerable similarity with members of the insulin‐receptor family such as c‐met and trk B. Also, the nyk‐r gene is expressed in a wide range of tissues and cell lines.