Swiveling and decatenation of replicating simian virus 40 genomes in vivo.
Open Access
- 1 February 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (2) , 515-521
- https://doi.org/10.1128/mcb.8.2.515
Abstract
We have found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication.This publication has 26 references indexed in Scilit:
- Selective extraction of polyoma DNA from infected mouse cell culturesPublished by Elsevier ,2004
- DNA topoisomerase II is required at the time of mitosis in yeastCell, 1985
- The termination region for SV40 DNA replication directs the mode of separation for the two sibling moleculesCell, 1985
- Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase IIScience, 1984
- Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.Journal of Biological Chemistry, 1984
- DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.Proceedings of the National Academy of Sciences, 1984
- Identification of Saccharomyces cerevisiae mutants deficient in DNA topoisomerase I activity.Journal of Biological Chemistry, 1984
- Arrest of segregation leads to accumulation of highly intertwined catenated dimers: Dissection of the final stages of SV40 DNA replicationCell, 1981
- Improved methods for the fluorographic detection of weak β-emitting radioisotopes in agarose and acrylamide gel electrophoresis mediaJournal of Biochemical and Biophysical Methods, 1981
- Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimersCell, 1980