Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II
- 26 October 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4673) , 466-468
- https://doi.org/10.1126/science.6093249
Abstract
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the molecular basis for its antitumor activity is unknown. Similar to a number of intercalative antitumor drugs and nonintercalative epipodophyllotoxins (VP-16 and VM-26), adriamycin has been shown to induce single- and double-strand breaks in DNA. These strand breaks are unusual because a covalently bound protein appears to be associated with each broken phosphodiester bond. In studies in vitro, mammalian DNA topoisomerase II mediates DNA damage by adriamycin and other related antitumor drugs.This publication has 17 references indexed in Scilit:
- Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.Proceedings of the National Academy of Sciences, 1984
- Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.Journal of Biological Chemistry, 1983
- The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering CellsScience, 1982
- DNA TopoisomerasesAnnual Review of Biochemistry, 1981
- THE ANTHRACYCLINESPublished by Elsevier ,1981
- Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerasesNucleic Acids Research, 1981
- DNA topoisomerasesCell, 1980
- Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand breakCell, 1980
- The Biology of Oxygen RadicalsScience, 1978
- Protein-associated DNA breaks in cells treated with adriamycin or ellipticineBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1978