ALLOGENEIC MARROW GRAFTING FOR ACUTE-LEUKEMIA - FOLLOW-UP OF LONG-TERM SURVIVORS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 7  (10) , 509-518
Abstract
One hundred consecutive patients were reported with refractory acute leukemia treated with chemotherapy, total body irradiation (TBI) and marrow from an HLA identical sibling. At the time of the report 17 patients were alive after 11-53 mo. All patients have now been followed more than 3 yr. At the time of the last report 4 of the 17 patients had relapsed: 2 in the marrow, 1 in the CNS and 1 in the testicle. Of these 4 patients 3 have died of their disease 27, 34 and 50 mo. following transplant. The patient with a solitary testicular relapse remains in complete remission 49 mo. after local irradiation without concomitant systemic therapy. One other patient died 26 mo. following transplantation from cardiopulmonary complications following multiple respiratory infections. Of the 13 surviving patients, 3 suffer from chronic graft-vs-host disease. Summeries of the problems encountered in these patients after the 1st 100 days were presented. Of the original 100 patients, 10 were living productive lives 36-80 mo. after transplantation. Long-term unmaintained remissions are possible in a small fraction of patients with terminal leukemia treated with various chemotherapy regimens and TBI followed by marrow transplantation.

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