Beta-adrenergic stimulation of the failing ventricle: a double-blind, randomized trial of sustained oral therapy with prenalterol.

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Abstract
Patients (11) with severe left ventricular impairment (mean ejection fraction 24%) and moderate impairment of exercise tolerance underwent a double-blind, placebo-controlled, crossover trial of the orally administered .beta.-agonist prenalterol. Exercise hemodynamics and tolerance were measured during bicycle and treadmill exercise after 2 wk of therapy with placebo or prenalterol. Cardiac index, ejection fraction and stroke work index were not improved and exercise duration and peak O2 consumption were not significantly different during the 2 treatments. During prenalterol treatment heart rate during exercise was consistently reduced. Prolonged therapy with prenalterol apparently does not improve hemodynamics or exercise tolerance, and is associated with a diminished heart rate response to exercise.