Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin‐haptoglobin uptake on human monocytes and macrophages
Open Access
- 14 February 2006
- journal article
- lipidomics
- Published by Wiley in Cytometry Part A
- Vol. 69A (3) , 203-205
- https://doi.org/10.1002/cyto.a.20235
Abstract
Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163‐mediated uptake of hemoglobin‐haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase‐1 expression and the secretion of pro‐ and antiinflammatory cytokines by macrophages. We found that increased availability of HbHp complexes triggers the upregulation of surface CD163, and also results in a dose‐dependent secretion of IL‐6 and IL‐10. © 2006 International Society for Analytical CytologyKeywords
This publication has 8 references indexed in Scilit:
- Human monocyte CD163 expression inversely correlates with soluble CD163 plasma levelsCytometry Part B: Clinical Cytometry, 2004
- CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory responseAnnals of Medicine, 2004
- Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase CEuropean Journal of Immunology, 2001
- Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediatesBiochemical Journal, 2001
- Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediatesBiochemical Journal, 2001
- Identification of the haemoglobin scavenger receptorNature, 2001
- Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuliJournal of Leukocyte Biology, 2000
- Genomic Organization and Chromosomal Localization of the Human CD163 (M130) Gene: A Member of the Scavenger Receptor Cysteine-Rich SuperfamilyBiochemical and Biophysical Research Communications, 1999