Synthesis and Evaluation of CC-1065 and Duocarmycin Analogues Incorporating the Iso-CI and Iso-CBI Alkylation Subunits: Impact of Relocation of the C-4 Carbonyl
- 1 December 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 62 (25) , 8875-8891
- https://doi.org/10.1021/jo971686p
Abstract
No abstract availableKeywords
This publication has 40 references indexed in Scilit:
- High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SAJournal of Molecular Biology, 1997
- Total Synthesis of (+)-Duocarmycin A, epi-(+)-Duocarmycin A and Their Unnatural Enantiomers: Assessment of Chemical and Biological PropertiesJournal of the American Chemical Society, 1997
- Covalent Modification of N3 of Guanine by (+)-CC-1065 Results in Protonation of the Cross-Strand CytosineJournal of the American Chemical Society, 1997
- A comparative study of the solvolysis reactivity, regioselectivity, and stereochemistry of the duocarmycin a and sa alkylation subunitsBioorganic & Medicinal Chemistry Letters, 1996
- Solution Structure of the Covalent Duocarmycin A-DNA Duplex ComplexJournal of Molecular Biology, 1995
- Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry.CHEMICAL & PHARMACEUTICAL BULLETIN, 1995
- A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-convalent van der waals contacts dominant in the non-covalent CC-1065/B-DNA bindingChemico-Biological Interactions, 1990
- Ortho functionalization of N-(tert-butoxycarbonyl)anilineThe Journal of Organic Chemistry, 1980
- 2-Thiazolines in organic synthesis. Synthesis of mono-, di-, and trialkylacetaldehydesThe Journal of Organic Chemistry, 1975
- Neighboring Carbon and Hydrogen. Li. Dienones from Ar1[UNK]-3 Participation. Isolation and Behavior of Spiro(2,5)octa-1,4-diene-3-oneJournal of the American Chemical Society, 1963