Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE ε4 carriers
- 23 August 2005
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 65 (4) , 642-644
- https://doi.org/10.1212/01.wnl.0000173055.75950.bf
Abstract
The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE ε4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in ε4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE ε4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.Keywords
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