Morphometric analysis of postnatal erythropoiesis in the spleen and bone marrow of the mouse.

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Abstract
Postnatal erythropoiesis in the spleen and bone marrow was morphometrically examined by EM in female mice. In the splenic red pulp, erythroblasts increased in number in early life, particularly until 20 days of age. On the basis of a cytometric analysis, erythroblasts were classified into 4 types: small, medium, large and extra-large. In the neonatal spleen, small erythroblasts constituted 16% of all the erythroblasts; medium, 55%; large, 23% and extra-large, 6%. In mice > 20 days old, medium erythroblasts were reduced in proportion and small erythroblasts accounted for > 50% of all erythroblasts. In the bone marrow, small erythroblasts represented the largest population until 40 days of age. At 60 days, medium erythroblasts were increased, being largest in proportion. The erythroblast types in the marrow at 60 days were similar in proportion to those in the neonatal spleen. An active state in erythrocytopoietic activity is suggested. The population pattern of erythroblasts may serve to evaluate erythrocytopoietic activity.