VARIATIONS IN PLASMA VOLUME AND HEMATOCRIT VALUES FOLLOWING HEMORRHAGE IN UNANESTHETIZED NORMAL, SPLENECTOMIZED AND SYMPATHECTOMIZED DOGS

Publisher Website
Google Scholar
Abstract
Unanesthetized normal, splenectomized, and sympathectomized dogs were bled from 25-45% of their blood vols. (dye and hematocrit readings). One hr. after hemorrhage, the red cell volume was greater in some animals and smaller in others than the value predicted (control red cell vol. minus red cell vol. removed). During the succeeding 1-4 days, the red cell vol. of all but one splenectomized dog decreased to a minimum which averaged 9% less than the value expected in the sympathectomized dogs. The corresponding values were 13% for the splenectomized and 20% for the normal dogs. Dilution alone cannot account for the decreased hematocrit value. The agreement between the reductions in red cell vol. and in the total number of red blood cells indicates that no decrease in the mean corpuscular volume has occurred. The linear correlation between the hematocrit reading and the Hb conc. as measured by the CO capacity shows that no change has occurred in the Hb content of the red cell. Detns. of urobilin demonstrate no increased post-hemorrhagic destruction of red cells. It is suggested that after hemorrhage red cells disappear into certain regions of the vascular bed where they are withdrawn from the active circulation.

This publication has 14 references indexed in Scilit: