Treatment of Felty's syndrome with low‐dose oral methotrexate

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Abstract
Recent studies of methotrexate in the treatment of patients with rheumatoid arthritis have precluded patients with neutropenia. We present a patient with rheumatoid arthritis complicated by severe neutropenia and recurrent infections, who was treated with low‐dose methotrexate, orally, for 30 months. The patient experienced symptomatic improvement and a significant increase in granulocyte count, and the dosage of steroids was reduced. Low‐dose oral methotrexate may be a therapeutic option in select patients with Felty's syndrome.

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