SULFUR METABOLISM IN CYSTINURIA 1

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Abstract
In a case of cystinuria accompanied by calculus formation, the cystine output was unchanged by daily administration over several mos. of alkali (NaHCO3 or Na citrate) but this evidently prevented deposition of calculi. Administration of equivalent amts. of glycine and glutamic acid had no effect on the rate of cystine excretion. Administered by mouth, 1-cystine was practically completely oxidized; dl-cystine was slightly less completely oxidized. Cysteic acid administration caused no increase in sulphate excretion. Methionine administration caused (1) no significant increase in cystine excretion (2) no excretion of homocystine and (3) definite but slight excretion of methionine as shown by the Baernstein method. An increase in the apparent free cystine content of these urines on standing was observed.

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