Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.
Open Access
- 1 September 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (9) , 3955-3959
- https://doi.org/10.1128/mcb.8.9.3955
Abstract
The binding sites for the 300-, 107-, and 105-kilodalton cellular proteins which associate with human adenovirus type 5 E1A products were studied with E1A deletion mutants. All appeared to bind to the amino-terminal half of E1A products in regions necessary for oncogenic transformation. These results suggest that these cellular species may be important for the biological activity of E1A products.This publication has 38 references indexed in Scilit:
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