A Study of the Drop-Outs in Psychopharmacological Research with Bulimics

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Abstract
Given the high drop-out rates frequently noted in drug trials with bulimic subjects, we have attempted to correlate drop-out status with a greater level of psychopathology as measured by a thorough standardized psychological assessment battery (NIMH-DIS, EDI, POMS and SCL-90). Despite a trend toward higher scores on the Paranoid Ideation Sub scale of the SCL-90 among drop-outs compared to completers, there were no significant differences found between the two groups participating in a fifteen week double blind crossover study on the effectiveness of desipramine in bulimia.