Tissue Oxygen Tension in the Anesthetized Patient

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Abstract
NORMAL cell metabolism and function depend on the constant presence of adequate amounts of oxygen within the cell. The amount of molecular oxygen in tissue (ie, tissue oxygen tension) is determined by a host of interrelated factors under normal conditions: Coefficient of oxygen diffusion Rate of delivery of oxygen to tissue Amount of oxygen in arterial blood Alveolar oxygen tension Oxygen tension in inspired air Alveolar ventilation Ventilation: perfusion ratio Pulmonary diffusion capacity Solubility of oxygen in plasma Amount of hemoglobin Rate of delivery of arterial blood to tissues Cardiac output Blood pressure State of peripheral vasculature (vasoconstricted or vasodilated) Arterio-venous shunts Rate at which oxygen leaves blood Oxygen dissociation curve Oxygen solubility in plasma Rate of consumption of oxygen by tissue Work Drugs Endocrine Epinephrine Corticosteroids Thyroxine Insulin Temperature Under conditions as physiologically and pharmacologically complex as clinical anesthesia, the determinants of tissue oxygenation become even more complex. Some