In vitro Action of Cortisone on Vasoconstriction Due to Histamine.

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Abstract
The influence of cortisone on histamine induced vasoconstriction was studied in 31 isolated surviving swine carotid arteries using an angi-oplethysmokymographic technic. Cortisone did not act as a physiological antagonist of histamine, nor did it act as a "blocking" drug. In concn. of 1 ppm. or greater cortisone accelerated the recovery of vascular smooth muscle from vasoconstriction due to histamine. This probably is due to an action of cortisone on the histamine inactivating enzyme systems. A significant seasonal variation in the reactivity of isolated swine arteries is noted.

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