Chronic Syndrome of Inappropriate Antidiuretic Hormone Secretion and Hypertension in a Patient With Olfactory Neuroblastoma

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Abstract
• A 28-year-old man with the chronic syndrome of inappropriate antidiuretic hormone secretion and hypertension was found to have an olfactory neuroblastoma. We demonstrated evidence of elevated circulating arginine vasopressin levels, significantly elevated arginine vasopressin and vasopressin neurophysin levels in the tumor extract, and immunohistochemical staining for arginine vasopressin and vasopressin neurophysin in the tumor cells. The patient's clinical syndrome, including hypertension, resolved following subtotal removal of the tumor and radiation therapy. This study identified olfactory neuroblastoma as a definite cause of ectopic arginine vasopressin secretion causing the syndrome of inappropriate antidiuretic hormone secretion. (Arch Intern Med1986;146:1731-1735)