Nicotine: a review of its role in atherosclerosis
- 30 November 2001
- journal article
- review article
- Published by Wolters Kluwer Health in Journal of the American College of Surgeons
- Vol. 193 (5) , 538-546
- https://doi.org/10.1016/s1072-7515(01)01059-6
Abstract
Overwhelming evidence is available associating cigarette smoking and several pathologic conditions, including cardiopulmonary disease and malignancies 1 Benditt E.P. Origins of human atherosclerotic plaques. The role of altered gene expression. Arch Pathol Lab Med. 1988; 112 : 997-1001 PubMed Google Scholar , 2 Hammond E.C. Horn D. The relationship between human smoking habits and death rates. JAMA. 1954; 155 : 1316-1328 Crossref PubMed Scopus (116) Google Scholar , 3 Woolf N. Wilson-Holt N.J. Cigarette smoking and atherosclerosis. in: Greenhalgh R.M. Smoking and Arterial Disease. Beekman Publishers, Inc, Woodstock, NY 1981: 46-59 Google Scholar ( Table 1). In the United States, one in six deaths is related to tobacco smoking. 11 Ravenholt R.T. Tobacco’s impact on 20th century US mortality patterns. Am J Prev Med. 1985; 1 : 4-7 PubMed Google Scholar Extensive research has been done over the past few decades aimed at understanding the pathophysiology of tobacco-related disease and elucidating the mechanisms by which tobacco smoke causes disease. Table 1 Putative Deleterious Effects of Smoking Atherosclerosis 3 Woolf N. Wilson-Holt N.J. Cigarette smoking and atherosclerosis. in: Greenhalgh R.M. Smoking and Arterial Disease. Beekman Publishers, Inc, Woodstock, NY 1981: 46-59 Google Scholar , 4 Mcbride P.E. The health consequences of smoking cardiovascular diseases. Med Clin North Am. 1992; 76 : 333-353 Crossref PubMed Scopus (146) Google Scholar , 5 Wilhelmsen L. Coronary heart disease epidemiology of smoking and intervention studies of smoking. Am Heart J. 1988; 115 : 242-249 Abstract Full Text PDF PubMed Scopus (147) Google Scholar Hypertension 6 PHS. Department of Health and Human Services. The health consequences of smoking: nicotine addiction. A report of the Surgeon General. Washington: Govt Printing Office 1988; DHSS CDC Publication No. 88-8406. Google Scholar Cerebrovascular accidents 7 Hecht S.S. Hoffman D. The relevance of tobacco-specific nitro-samines to human cancer. Cancer Surv. 1989; 8 : 272-294 Google Scholar Cancer 7 Hecht S.S. Hoffman D. The relevance of tobacco-specific nitro-samines to human cancer. Cancer Surv. 1989; 8 : 272-294 Google Scholar Chronic lung disease 8 Totti III, N. McCusker K.T. Campbell E.L. et al. Nicotine is chemotactic for neutrophils and enhances neutrophils and enhances neutrophil responsiveness to chemotactic peptides. Science. 1984; 223 : 169-173 Crossref PubMed Scopus (117) Google Scholar Ischemic heart disease 9 Taylor A.E. Johnson D.C. Kazemi H. Environmental tobacco smoke and cardiovascular disease. A position paper from the council on cardiopulmonary and critical care, American Heart Association. Circulation. 1992; 86 : 699 Crossref PubMed Scopus (152) Google Scholar Hypercoagulability 10 Taylor B.V. Oudit G.Y. Kalman P.G. et al. Clinical and pathophysiological effects of active and passive smoking on the cardiovascular system. Can J Cardiol. 1998; 14 : 1129 PubMed Google Scholar Open table in a new tabKeywords
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