Human Cytomegalovirus Open Reading Frame TRL11/IRL11 Encodes an Immunoglobulin G Fc-Binding Protein
- 15 November 2001
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (22) , 11218-11221
- https://doi.org/10.1128/jvi.75.22.11218-11221.2001
Abstract
Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.Keywords
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