THE ACCUMULATION OF LACTIC ACID IN EXCISED BRAIN, KIDNEY, MUSCLE AND TESTICLE

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Abstract
The lactic acid content of the brain, kidney and muscle of normal dogs (decapitated) was remarkably constant. The brain contained 50-70 mgm., the kidney 10-30 mgm., and muscle 15-35 mgm. of lactic acid per 100 gm. of tissue. The lactic acid content of the normal testicle, however, was extremely variable, possibly because of age differences. Under complete asphyxiation there was a marked difference in the rate of lactic acid formation in the various tissues. The initial content of the brain rose approximately SO mgm. % in 10 min. whereas in the kidney, muscle and testicle the increase was approximately 35, 50 and 15 mgm. ''% respectively. The differences in the rate of lactic acid formation in the various tissues may be due to different concentrations of enzymes controlling lactic acid metabolism.

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