Palladium-Catalyzed Oxygenation of Unactivated sp3 C−H Bonds
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- 16 July 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (31) , 9542-9543
- https://doi.org/10.1021/ja046831c
Abstract
This communication describes a new palladium-catalyzed method for the oxygenation of unactivated sp3 C−H bonds. A wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups are oxidized with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity. The substrate scope of these reactions is discussed, and the high selectivities are rationalized on the basis of the requirements of putative palladium alkyl intermediates.Keywords
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