Blood Glucose and Corticosterone Changes Accompanying Altered Lipid Metabolism Induced by Exposure to Acceleration Stress
- 1 January 1966
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 121 (1) , 223-227
- https://doi.org/10.3181/00379727-121-30742
Abstract
Summary Fasted, male, Sprague-Dawley rats were exposed to 4.7 g for periods of time up to 24 hours. Plasma glucose, plasma corticosterone, liver lipids, and incorporation of acetate-1-C14 into fatty acids in liver slices were followed in rats exposed for periods of 1–24 hours. Plasma glucose and plasma corticosterone curves were bimodal showing an early maximum during the first 3 hours of exposure and rising after 5 hours through the 24-hour study. During the second rise the greatest changes in lipid metabolism were noted as a decrease in liver lipid and an increase in fatty acid synthesis. The responses evoked by the stress were abolished by hypophysectomy or adrenalectomy. It is concluded that changes in fat metabolism induced by acceleration stress were mediated, in part, by changes in levels of circulating glucose, corticosterone, or the interaction of both.This publication has 1 reference indexed in Scilit:
- Conversion of acetate to lipids and CO2 by liver of rats exposed to acceleration stressAmerican Journal of Physiology-Legacy Content, 1965