Changes in Steady State Digoxin Pharmacokinetics during Quinidine Therapy in Cardiac Patients: Influence of Plasma Quinidine Concentration

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Abstract
In seven cardiac patients on long‐term digoxin therapy, digoxin kinetics were investigated — in the absence and presence of quinidine — after simultaneous administration of an oral digoxin dose and an intravenous 3H‐digoxin bolus injection. From 3H‐digoxin data quinidine was found to decrease both renal (from 1.19 ±0.35 to 0.86 ±0.21 ml/min./kg) (P3H‐digoxin clearance occurred at subtherapeutic plasma quinidine levels and was independent of plasma quinidine, whereas reductions in extrarenal 3H‐digoxin clearance and 3H‐digoxin distribution volume were positively correlated to plasma quinidine concentrations (P<0.05).

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