The Influence of Plasma Volume Expanders on Initial Haemostasis in the Rabbit Mesentery

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Abstract
An experimental study was undertaken to evaluate the effect of dose (1 and 2 g/kg b. w.) and molecular weight (40 000, 70 000, 110 000 and 500 000 daltons) of dextran on primary haemostatic plug formation in the rabbit mesenteric microcirculation. All experiments were made 3 h after the infusion of the different substances. Albumin and hydro‐oxyethyl starch treatment was used for control plasma volume expansion and did not influence arteriolar and venular haemostasis as compared with saline. Dextran gave a prolonged haemostatic plug formation time with increasing dose and with increasing molecular weights. Clinically relevant doses of dextran 40 and 70 (1 g/kg b. w.) did not influence haemostatic plug formation time.