RAPID DISAPPEAEANCE OF PROGESTERONE FROM OILY SOLUTIONS INJECTED INTRAPERITONEALLY IN MICE1

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Abstract
Seventy-five to 22,500 µg. of progesterone dissolved in 1.5 ml. sesame oil were injected intraperitoneally into ovariectomized adult CHI mice. They were exsanguinated two and one-half minutes to eight hours later, and the gestagen levels in the plasma and in the oil recovered from the peritoneal cavities were determined by bio-assay. Concentrations in the plasma were found to have risen quickly and to have declined within an hour. Concentrations in the recovered oil fell to 60µg. or less within 10 minutes and to about 12 µg. in 30 minutes, regardless of the original concentration of the injected solution.