Inactivity of Bound Plasma Progesterone.

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Abstract
Pellets of crystalline progesterone implanted into the spleens of ovariec-tomized mice had no effect upon the endometrium despite the presence of relatively high levels of bound progesterone in the plasma; the highest level of free progesterone in these animals was 0.7 [mu]g./ml. Subcut. pellets of progesterone produced characteristic progestational changes in the endometrium when the level of free plasma progesterone exceeded 1 [mu]g./ml. Binding appears to be a mechanism of hepatic inactivation of progesterone in the mouse.