Prostatic acid phosphatase by radioimmunoassay. Sensitivity compared with enzymatic assay

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Abstract
Prostatic acid phosphatase values in 98 patients with prostatic carcinoma were measured by a commercial radioimmunoassay (RIA) and by enzymatic assay. Forty-three carcinomas were staged by rigorous pathological criteria. Patients (129) with benign prostatic hyperplasia were the control group. At 94% specificity, sensitivities of the RIA vs. the enzymatic assay for clinically staged patients were as follows; stage A, 22% vs. 6%; B, 29% vs. 10%; C, 52% vs. 38%; and D, 87% vs. 80%. However, none of the 7 patients with pathological stage A and B disease had a positive test result; variability in staging criteria accounts for the discrepant sensitivity claims reported. Prostatic acid phosphatase RIA should not be used for screening but as an adjunct for staging known as prostatic carcinoma.