Albumin Binding and Hepatic Uptake: The Importance of Model Selection—A Response
- 1 October 1983
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 72 (10) , 1233
- https://doi.org/10.1002/jps.2600721039
Abstract
No abstract availableKeywords
This publication has 7 references indexed in Scilit:
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- Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ modelsJournal of Pharmacy and Pharmacology, 1983
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- Albumin helps mediate removal of taurocholate by rat liver.Journal of Clinical Investigation, 1981
- Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparationJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparationJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearanceJournal of Pharmacokinetics and Biopharmaceutics, 1977