Therapy for acute cystitis in adult women. Randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole

Publisher Website
Google Scholar
Abstract
Women [117] with symptoms of acute cystitis were randomized to groups for immediate therapy with 1 of the following 4 single-dose regimens: 1 g sulfisoxazole, 2 g sulfisoxazole, a combination of trimethoprim, 160 mg, and sulfamethoxazole, 800 mg and a combination of trimethoprim, 320 mg, and sulfamethoxazole, 1600 mg. Forty-one women were excluded, 13 did not return for follow-up and 28 did not have significant bacteriuria in the pretherapy culture. Escherichia coli was isolated in 81% of infections. Antibacterial activity was significantly greater in urine collected during the 24 h after therapy in those who received trimethoprim-sulfamethoxazole. Overall cure varied from 85-95%, without any great differences between the regimens. The rate of cure of 69% in the 13 patients with presumptive evidence of renal infection (antibody-coated bacteria present) was significantly lower than the rate of cure of 95% in women without evidence of renal infection. Single-dose therapy with these regimens was safe and effective in adult women with symptoms of acute cystitis, regardless of the localization of the site of infection.