Effect of nifedipine on serum digoxin concentration and renal digoxin clearance

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Abstract
Nifedipine has been reported either to decrease or not to affect digoxin elimination. The effect of oral nifedipine on steady-stae digoxin concentrations and renal clearance in 20 healthy male subjects was studied. After 2 wk of digitalization, all recieved digoxin, 0.375 mg/day, with placebo for 2 wk, then digoxin and nifedipine, 18.5 .+-. 4 mg every 8 h, for 2 wk, and then digoxin with placebo for 2 wk. Mean (.+-. SD) digoxin concentrations of 0.74 .+-. 0.20 and 0.75 .+-. 0.25 ng/ml on placebo were not altered by nifedipine (0.77 .+-. 0.23 ng/ml). Digoxin clearance was 2.2 .+-. 0.6 and 2.7 .+-. 0.8 ml/kg per min on placebo and 2.5 .+-. 0.6 ml/kg per min on nifedipine. No change in pharmacologic effect of digoxin by nifedipine was observed, but mean blood pressure was lower and heart rates were accelerated. Oral nifedipine evidently does not alter digoxin concentrations or decrease renal clearance in healthy subjects.